Signal-peptide peptidase, presenilin aspartyl protease (IPR010545)

Short name: SPP

Family relationships


SPP is a family of signal-peptide aspartyl proteases. The family carries the characteristic catalytic aspartate GXGD motif, and members are integral membrane peptidases of the presenilin-type with nine transmembrane regions. UniProtKB:Q18K19 (Q18K19) is part of the TCDB family 1.A.54.3.4, the presenilin er Ca(2+) leak channel (presenilin) [PMID: 23254940].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.