Auxin response factor (IPR010525)

Short name: Auxin_resp

Overlapping homologous superfamilies


Domain relationships



This pattern represents a conserved region of auxin-responsive transcription factors.

The plant hormone auxin (indole-3-acetic acid) can regulate the gene expression of several families, including Aux/IAA, GH3 and SAUR families. Two related families of proteins, Aux/IAA proteins (IPR003311) and the auxin response factors (ARF), are key regulators of auxin-modulated gene expression [PMID: 12036262]. There are multiple ARF proteins, some of which activate, while others repress transcription. ARF proteins bind to auxin-responsive cis-acting promoter elements (AuxREs) using an N-terminal DNA-binding domain. It is thought that Aux/IAA proteins activate transcription by modifying ARF activity through the C-terminal protein-protein interaction domains found in both Aux/IAA and ARF proteins.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0009725 response to hormone

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.