Domain

Collagenase NC10/endostatin (IPR010515)

Short name: Collagenase_NC10/endostatin

Domain relationships

Description

NC10 stands for Non-helical region 10 and is taken from P39059. A mutation in this region in P39060 is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumour suppressor and has been used highly successfully to treat cancer. It is a potent angiogenesis inhibitor [PMID: 11606364].

Endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes. This domain has a compact globular fold similar to that of C-type lectins. Endostatin XVIII is monomeric and contains a heparin-binding epitope and zinc binding sites [PMID: 10704302] while endostatin XV is trimeric and contains neither of these sites. The generation of endostatin or endostatin-like collagen XV/XVIII fragments is catalyzed by proteolytic enzymes within the protease-sensitive hinge region of the C-terminal domain. Endostatin inhibits endothelial cell migration in vitro and appears to be highly effective in murine in vivo studies [PMID: 10885579,PMID: 11191058].

GO terms

Biological Process

GO:0007155 cell adhesion

Molecular Function

GO:0005198 structural molecule activity

Cellular Component

GO:0031012 extracellular matrix

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
CDD