Arfaptin homology (AH) domain (IPR010504)

Short name: AH_dom

Overlapping homologous superfamilies

Domain relationships


The arfaptin homology (AH) domain is a protein domain found in a range of proteins, including arfaptins, protein kinase C-binding protein PICK1 [PMID: 10623590] and mammalian 69 kDa islet cell autoantigen (ICA69) [PMID: 12682071]. The AH domain of arfaptin has been shown to dimerise and to bind Arf and Rho family GTPases [PMID: 11346801, PMID: 11696355], including ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules.

The AH domain consists of three alpha-helices arranged as an extended antiparallel alpha-helical bundle. Two arfaptin AH domains associate to form a highly elongated, crescent-shaped dimer [PMID: 11346801, PMID: 11696355].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0019904 protein domain specific binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles