Domain

Formin, GTPase-binding domain (IPR010473)

Short name: GTPase-bd

Domain relationships

None.

Description

Diaphanous-related formins (Drfs) are a family of formin homology (FH) proteins that act as effectors of Rho small GTPases during growth factor-induced cytoskeletal remodelling, stress fibre formation, and cell division [PMID: 10631086]. Drf proteins are characterised by a variety of shared domains: an N-terminal GTPase-binding domain (GBD), formin-homology domains FH1, FH2 (IPR015425) and FH3 (IPR010472), and a C-terminal conserved Dia-autoregulatory domain (DAD) that binds the GBD.

This entry represents the GBD, which is a bifunctional autoinhibitory domain that interacts with and is regulated by activated Rho family members. Mammalian Drf3 contains a CRIB-like motif within its GBD for binding to Cdc42, which is required for Cdc42 to activate and guide Drf3 towards the cell cortex where it remodels the actin skeleton [PMID: 12676083].

GO terms

Biological Process

GO:0030036 actin cytoskeleton organization

Molecular Function

GO:0017048 Rho GTPase binding
GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART