Ribosomal L11 methyltransferase, PrmA (IPR010456)

Short name: Ribosomal-L11_MeTrfase_PrmA

Family relationships


This family consists of several Ribosomal protein L11 methyltransferase sequences. Its genetic determinant is prmA, which forms a bifunctional operon with the downstream panF gene [PMID: 8226664]. The role of L11 methylation in ribosome function is, as yet, unknown. Deletion of the prmA gene in Escherichia coli showed no obvious effect [PMID: 15317787] except for the production of undermethylated forms of L11 [PMID: 7715456]. Methylation is the most common post-transcriptional modification to ribosomal proteins in all organisms. PrmA is the only bacterial enzyme that catalyses the methylation of a ribosomal protein [PMID: 12777815].

GO terms

Biological Process

GO:0006479 protein methylation

Molecular Function

GO:0008276 protein methyltransferase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.