Family

Isocitrate dehydrogenase kinasephosphatase (IPR010452)

Short name: Isocitrate_DH_AceK

Family relationships

None.

Description

This family consists of several bacterial isocitrate dehydrogenase kinase/phosphatase (ICDH kinase/phosphatase) proteins. The enzyme has no activating compound but is specific for its substrate. It is a bifunctional enzyme that catalyses the reversible phosphorylation of isocitrate dehydrogenase (IDH, EC:1.1.1.42) on a seryl residue. It consequently belongs to the serine/threonine protein kinase family [PMID: 11258918], and it acts in the Krebs cycle [PMID: 11751849]. The catalytic activities of ICDH kinase/phosphatase constitute a moiety conserved cycle, require ATP, and exhibit 'zero-order ultrasensitivity' [PMID: 16415587].

GO terms

Biological Process

GO:0006006 glucose metabolic process

Molecular Function

GO:0008772 [isocitrate dehydrogenase (NADP+)] kinase activity
GO:0016791 phosphatase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP
PIRSF
ProDom
Pfam