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Overview
Acetoacetate decarboxylase (IPR010451)
Short name: Acetoacetate_decarboxylase
Overlapping homologous superfamilies
- Acetoacetate decarboxylase domain superfamily (IPR023375)
Family relationships
- Acetoacetate decarboxylase (IPR010451)
- Acetoacetate decarboxylase, bacterial (IPR023653)
- Enduracididine biosynthesis enzyme MppR (IPR031022)
Description
Acetoacetate decarboxylase (ADC) is involved in solventogenesis in certain bacteria, which occurs at the end of the exponential growth phase when there is a metabolic switch from classical sugar fermentation with the production of acetate and butyrate to the re-internalisation and oxidation of these acids to acetate and butanol [PMID: 11824611]. In Clostridium, SpoOA controls the switch from acid to solvent production. A SpoAO-binding motif occurs in the gene encoding ADC [PMID: 10972834].
This family also contains the fungal decarboxylase DEC1 encoded by the Tox1B locus, which along with the Tox1A gene product is required for the production of the polyketide T-toxin. The pathogenic fungus Cochliobolus heterostrophus (Drechslera maydis) requires the T-toxin for high virulence to maize with T-cytoplasm [PMID: 12236595].
GO terms
Biological Process
No terms assigned in this category.
Molecular Function
GO:0016829 lyase activity
Cellular Component
No terms assigned in this category.
Contributing signatures
- PF06314 (ADC)