Neurexophilin (IPR010450)

Short name: Nxph

Family relationships


Neurexophilins (Nxphs) comprise a family of glycoproteins (Nxph1-4) that exhibit characteristics of secreted, preproprotein-derived molecules [PMID: 25157101]. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins [PMID: 9570794].

Nxph1 plays an instructive role in synaptic short-term plasticity and the configuration with GABA receptors [PMID: 24639499]. Nxph3 has been shown to support the survival of mouse induced pluripotent stem cell-derived (iPSC-derived) dopaminergic (DA) neurons in vitro and in vivo [PMID: 26041738].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.