Calcium-dependent secretion activator domain (IPR010439)

Short name: CAPS_dom

Overlapping homologous superfamilies


Domain relationships



This entry represents a domain found in the calcium-dependent secretion activators that are involved in the exocytosis of vesicles filled with neurotransmitters and neuropeptides. They also may specifically mediate the Ca2+-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion [PMID: 15820695]. However, it probably also participates in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca2+ triggering [PMID: 11516399].

This protein is often found in tandem repeats and co-occur with C2 domains IPR000008, Protein kinase C, phorbol ester/diacylglycerol binding regions IPR002219 and PH domains IPR001849.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.