Domain

Signaling lymphocytic activation molecule, N-terminal (IPR010407)

Short name: Sig_lymph_act_molc_N

Domain relationships

None.

Description

This entry is found in several mammalian signalling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM, a 70 kDa co-stimulatory molecule belonging to the Ig superfamily, is defined as a human cell surface molecule that mediates CD28-independent proliferation of human T cells and IFN-gamma production by human Th1 and Th2 clones [PMID: 10570270]. SLAM has also been recognised as a receptor for Measles virus [PMID: 12610126].

GO terms

Biological Process

GO:0046649 lymphocyte activation

Molecular Function

GO:0004872 receptor activity

Cellular Component

GO:0009986 cell surface
GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
ProDom