Cofactor of BRCA1 (IPR010405)

Short name: COBRA1

Overlapping homologous superfamilies


Family relationships



This family consists of several cofactor of BRCA1 (COBRA1) proteins (also known as negative elongation factor B). It is thought that COBRA1 along with BRCA1 is involved in chromatin unfolding. COBRA1 is recruited to the chromosome site by the first BRCT repeat of BRCA1, and is itself sufficient to induce chromatin unfolding. BRCA1 mutations that enhance chromatin unfolding also increase its affinity for, and recruitment of, COBRA1. It is thought that that reorganisation of higher levels of chromatin structure is an important regulated step in BRCA1-mediated nuclear functions [PMID: 11739404].

GO terms

Biological Process

GO:0045892 negative regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.