PITH domain (IPR010400)

Short name: PITH_dom

Overlapping homologous superfamilies

Domain relationships



This entry represents the PITH domain (derived from Proteasome-Interacting THioredoxin). The protein Txnl1, which is a probable component of the 32kDa 26S proteasome, uses its C-terminal PITH domain to associate specifically with the 26S proteasome [PMID: 19349277].

The PITH domain is dominated by a jelly roll beta-sandwich structure. The beta-sandwich is formed by face-to-face packing of two anti-parallel beta-sheets. Another two-stranded beta-sheet seals off one end of the beta-barrel [PMID: 15741346, PMID: 20455272].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles