Family

5-nucleotidase (IPR010394)

Short name: 5-nucleotidase

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

This family consists of both eukaryotic and prokaryotic 5'-nucleotidase sequences (EC:3.1.3.5), including cytosolic 5'-nucleotidase 1A and 1B (NT5C1A/NT5C1B) from mammals. NT5C1A/NT5C1B dephosphorylate the 5' and 2'(3')-phosphates of deoxyribonucleotides and help to regulate adenosine levels [PMID: 11133996].

GO terms

Biological Process

GO:0009117 nucleotide metabolic process

Molecular Function

GO:0008253 5'-nucleotidase activity
GO:0000287 magnesium ion binding
GO:0000166 nucleotide binding

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam