MtfA family (IPR010384)

Short name: MtfA_fam

Overlapping homologous superfamilies


Family relationships



MtfA (previously known as YeeI) is a transcription factor A that binds Mlc (make large colonies), itself a repressor of glucose and hence a protein important in regulation of the phosphoenolpyruvate:glucose-phosphotransferase (ptsG) system, the major glucose transporter in E. coli. Mlc is a repressor of ptsG, and MtfA is found to bind and inactivate Mlc with high affinity [PMID: 16855233]. The membrane-bound protein EIICBGlc encoded by the ptsG gene is the major glucose transporter in Escherichia coli. MtfA is found to be a glucose-regulated peptidase [PMID: 22178967], whose activity is regulated by binding to Mlc available in the cytoplasm, which in turn has been released from EIICBGlc during times when no glucose is taken up. A physiologically relevant target for this peptidase is not yet known.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.