Family

Brain/reproductive organ-expressed protein (IPR010358)

Short name: Brain/reproduct-express_prot

Family relationships

None.

Description

This family consists of several eukaryotic brain and reproductive organ-expressed (BRE) proteins. BRE is a putative stress-modulating gene, found able to down-regulate TNF-alpha-induced-NF-kappaB activation upon over expression. A total of six isoforms are produced by alternative splicing predominantly at either end of the gene. Compared to normal cells, immortalised human cell lines uniformly express higher levels of BRE. Peripheral blood monocytes respond to LPS by down-regulating the expression of all the BRE isoforms. It is thought that the function of BRE and its isoforms is to regulate peroxisomal activities [PMID: 11676476].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam