Family

Tyrosyl-DNA phosphodiesterase I (IPR010347)

Short name: Tdp1

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate [PMID: 12023295, PMID: 19505854].

Mutations in human TDP1 gene cause spinocerebellar ataxia, autosomal recessive, with axonal neuropathy (SCAN1), which is a clinically and genetically heterogeneous group of cerebellar disorders [PMID: 16141202].

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0008081 phosphoric diester hydrolase activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER