Family

Interleukin-17 family (IPR010345)

Short name: IL-17_fam

Family relationships

Description

Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells.

Interleukin-17 (IL-17) is a potent proinflammatory cytokine produced by activated memory T cells [PMID: 11781375]. The IL-17 family (of which there are 6 known members, termed IL-17A to IL-17F) is thought to represent a distinct signalling system that appears to have been highly conserved across vertebrate evolution [PMID: 11781375]. Family members play an active role in inflammatory diseases, autoimmune diseases and cancer [PMID: 15485625].

This entry represents interleukin-17 family IL-17A to IL-17F. Interleukin-17E has been renamed as interleukin-25 (IL-25)

GO terms

Biological Process

GO:0006954 inflammatory response

Molecular Function

GO:0005125 cytokine activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam