mRNA-decapping enzyme subunit 1 (IPR010334)

Short name: Dcp1

Overlapping homologous superfamilies


Family relationships



An essential step in mRNA turnover is decapping. In yeast, two proteins have been identified that are essential for decapping, Dcp1 (this family) and Dcp2. Dcp1 is a coactivator that binds to the decapping enzyme Dcp2 and forms a decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation [PMID: 16341225]. Yeast Dcp1 interact directly with Dcp2, however, the Dcp1-Dcp2 interaction is promoted by an additional factor, EDC4 [PMID: 24510189].

GO terms

Biological Process

GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0043085 positive regulation of catalytic activity

Molecular Function

GO:0008047 enzyme activator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.