3-hydroxyanthranilic acid dioxygenase (IPR010329)

Short name: 3hydroanth_dOase

Overlapping homologous superfamilies

Family relationships


Members of this protein family, from both bacteria and eukaryotes, are the enzyme 3-hydroxyanthranilate 3,4-dioxygenase (EC: It is part of the kynurenine pathway for the degradation of tryptophan and the biosynthesis of nicotinic acid [PMID: 9539135].The prokaryotic homologue is involved in the 2-nitrobenzoate degradation pathway [PMID: 12620844].

The enzyme acts on the tryptophan metabolite 3-hydroxyanthranilate and produces 2-amino-3-carboxymuconate semialdehyde, which can rearrange spontaneously to quinolinic acid and feed into nicotinamide biosynthesis, or undergo further enzymatic degradation.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity
GO:0005506 iron ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.