FldB/FldC dehydratase alpha/beta subunit (IPR010327)

Short name: FldB/FldC_alpha/beta

Overlapping homologous superfamilies


Family relationships


This entry includes HgdA/B from Acidaminococcus fermentans, FldB/C from Clostridium sporogenes and BcrB/C from Thauera aromatica. Acidaminococcus fermentans 2-hydroxyglutaryl-CoA dehydratase consists of two components: A (for activator or initiator) and D (for dehydratase). HgdA and B form a heterodimeric enzyme designated as component D, which contains an oxidized [4Fe-4S]2+ cluster and reduced riboflavin-5'-phosphate.

Clostridium sporogenes phenyllactyl-CoA dehydratase subunits (FldB/C) show significant sequence similarities to both subunits of 2-hydroxyglutaryl-CoA dehydratase (HgdA/B). FldB/C heterodimeric enzyme (a phenyllactyl-CoA dehydratase) catalyses the dehydration of phenyllactyl-CoA to cinnamoyl-CoA [PMID: 11967068].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.