Family

Transglutaminase-like cysteine peptidase, predicted (IPR010319)

Short name: Transglutaminase-like_Cys_pept

Family relationships

None.

Description

Structural analysis predicts that this family of proteins are bacterial transglutaminase-like cysteine peptidases (BTLCPs) with an invariant Cys-His-Asp catalytic triad and an N-terminal signal sequence. They are predicted to possess the papain-like cysteine proteinase fold and catalyse post-translational protein modification through transamidase, acetylase or hydrolase activity. Inspection of neighbouring genes suggests a link between this predicted activity and a type-I secretion system resembling ATP-binding cassette exporters of toxins and proteases involved in bacterial pathogenicity [PMID: 15288868].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam