Redox-sensitive transcriptional activator SoxR (IPR010211)

Short name: Redox-sen_tscrpt-act_SoxR

Overlapping homologous superfamilies

Family relationships



SoxR is a MerR-family homodimeric transcription factor with a 2Fe-2S cluster in each monomer. The motif CIGCGCxxxxxC is conserved. Oxidation of the iron-sulphur cluster activates SoxR. The physiological role in Escherichia coli is response to oxidative stress. It is activated by superoxide, singlet oxygen, nitric oxide (NO), and hydrogen peroxide. In E. coli, SoxR increases expression of transcription factor SoxS; different downstream targets may exist in other species [PMID: 12670967].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0006979 response to oxidative stress

Molecular Function

GO:0051537 2 iron, 2 sulfur cluster binding
GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.