Family

Na(+)-translocating NADH-quinone reductase subunit F (IPR010205)

Short name: NqrF

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

NADH:ubiquinone oxidoreductase (complex I) (EC:1.6.5.3) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [PMID: 1470679]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [PMID: 10940377], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins [PMID: 18394423].

This entry represents the Na(+)-translocating E subunit from NADH:ubiquinone oxidoreductase from a number of marine and pathogenic Gram-negative bacteria [PMID: 15010474, PMID: 11248187].

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0006814 sodium ion transport

Molecular Function

GO:0051537 2 iron, 2 sulfur cluster binding
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
HAMAP
PIRSF