HflK (IPR010201)

Short name: HflK

Overlapping homologous superfamilies

Family relationships


The accumulation of abnormal membrane proteins is something which must be avoided in order to maintain cell viability. In Escherichia coli, the membrane-bound, ATP-dependent protease FtsH plays a central role in the degradation of these abnormal proteins [PMID: 15910274]. Known substrates of this protease include several lambda bacteriophage proteins, the heat-shock transcription factor sigma-32, and the unassembled form of the membrane protein SecY. While FtsH is active as a protease on its own, in vivo it forms a complex with a membrane-bound HflKC heterodimer. HflKC has a generally inhibitory effect on the protease activity of FtsH, though the mechanism of this inhibition is not known. HflK is a member of peptidase inhibitor family I87 [PMID: 20430064]. The HflK and HflC polypeptides are paralogous, and often encoded by tandem genes within bacterial genomes.

This entry represents the HflK subunit (MEROPS identifier I87.002) of the HflKC heterodimer.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.