o-Succinylbenzoate synthase, MenC type 2 (IPR010197)

Short name: OSB_synthase_MenC_2

Overlapping homologous superfamilies

Family relationships



This entry describes the enzyme o-succinylbenzoic acid synthetase (menC) that is involved in one of the steps of the menaquinone biosynthesis pathway. It takes SHCHC and makes it into 2-succinylbenzoate. Also included are enzymes with the common name of N-acylamino acid racemase (NAAAR, or the more general term, racemase / racemase family), which refers to the enzyme's industrial application as a racemase that catalyses the racemization of N-acylamino acids, and not to its biological function as o-succinylbenzoic acid synthetase [PMID: 10194342]. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building blocks for antibiotics, herbicides, and drugs. Most members of this group of o-succinylbenzoate synthases are proteins from low GC Gram-positive bacteria and archaea. menC/NAAAR is a member of the enolase superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion [PMID: 15313614, PMID: 15134446].

GO terms

Biological Process

GO:0009234 menaquinone biosynthetic process

Molecular Function

GO:0016829 lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.