o-Succinylbenzoate synthase, MenC type1 (IPR010196)

Short name: OSB_synthase_MenC1

Overlapping homologous superfamilies

Family relationships



This entry describes the enzyme o-succinylbenzoic acid synthetase (MenC) that is involved in one of the steps of the menaquinone biosynthesis pathway. The biosynthesis of menaquinone has been studied most in Escherichia coli [PMID: 11153266]. 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) is dehydrated by MenC to give the aromatic compound O-succinylbenzoate (OSB) [PMID: 8335646]. MenC, which is a member of the enolase superfamily and x-ray structure has been determined [PMID: 10194342, PMID: 10978150]. Many of the common names of the proteins in this family are incorrectly described as O-succinylbenzoyl-CoA synthase. Members are restricted to bacteria.

GO terms

Biological Process

GO:0009234 menaquinone biosynthetic process

Molecular Function

GO:0016836 hydro-lyase activity
GO:0000287 magnesium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.