2-succinylbenzoate--CoA ligase (IPR010192)

Short name: MenE

Family relationships



This entry represents the enzyme O-succinylbenzoate-CoA ligase (MenE), which is involved in the fourth step of the menaquinone (vitamin K2) biosynthesis pathway. In bacteria, menaquinone is used during fumarate reduction in anaerobic respiration. In green sulphur bacteria and heliobacteria, menaquinones are thought to be used as a loosely bound secondary electron acceptor in the photosynthetic reaction centre. In cyanobacteria, the product of the menaquinone pathway is phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone), a molecule used exclusively as an electron transfer cofactor in Photosystem (PS) I [PMID: 12615349].

GO terms

Biological Process

GO:0009234 menaquinone biosynthetic process

Molecular Function

GO:0005524 ATP binding
GO:0008756 o-succinylbenzoate-CoA ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.