Acetylornithine deacetylase ArgE (IPR010169)

Short name: AcOrn-deacetyl

Overlapping homologous superfamilies

Family relationships

  • Peptidase M20 (IPR002933)
    • Acetylornithine deacetylase ArgE (IPR010169)


Acetylornithine deacetylase (ArgE, also known as acetylornithinase, AO or N2-acetyl-L-ornithine amidohydrolase) catalyzes the conversion of N-acetylornithine to ornithine, which can then be incorporated into the urea cycle for the final stage of arginine synthesis. The substrate specificity of ArgE is quite broad; several alpha-N-acyl-L-amino acids can be hydrolyzed, including alpha-N-acetylmethionine and alpha-N-formylmethionine [PMID: 17333302, PMID: 16201833, PMID: 10684608]. ArgE shares significant sequence homology and biochemical features, and possibly a common origin, with glutamate carboxypeptidase (CPG2) and succinyl-diaminopimelate desuccinylase (DapE), and aminoacylase I (ACY1), having all metal ligand binding residues conserved [PMID: 1628835].

GO terms

Biological Process

GO:0006526 arginine biosynthetic process

Molecular Function

GO:0008777 acetylornithine deacetylase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.