Family

Amidase, carbamoylase-type (IPR010158)

Short name: Amidase_Cbmase

Family relationships

Description

L-carbamoylases (N-carbamoyl-L-amino-acid amidohydrolases) hydrolyze the amide bond of the carbamoyl group in L-N-carbamoyl-amino acids [PMID: 16254442]. They are important industrial enzymes widely used for the production of optically pure amino acids due to their stereospecificity. Furthermore, their substrate promiscuity allows their use in different multienzymatic processes [PMID: 20730754, PMID: 19830420].

Also included in this family is allantoate amidohydrolase (allantoate deiminase), which catalyzes the conversion of allantoate to (S)-ureidoglycolate, one of the crucial alternate steps in purine metabolism [PMID: 17362992], and yeast N-carbamyl-beta-alanine amidohydrolase (betaAS, beta-alanine synthase) [PMID: 17916556, PMID: 14534321].

These enzymes are members of the broader family of amidases.

GO terms

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
PANTHER
TIGRFAMs
PIRSF