Amidase, carbamoylase-type (IPR010158)

Short name: Amidase_Cbmase

Overlapping homologous superfamilies


Family relationships


L-carbamoylases (N-carbamoyl-L-amino-acid amidohydrolases) hydrolyze the amide bond of the carbamoyl group in L-N-carbamoyl-amino acids [PMID: 16254442]. They are important industrial enzymes widely used for the production of optically pure amino acids due to their stereospecificity. Furthermore, their substrate promiscuity allows their use in different multienzymatic processes [PMID: 20730754, PMID: 19830420].

Also included in this family is allantoate amidohydrolase (allantoate deiminase), which catalyzes the conversion of allantoate to (S)-ureidoglycolate, one of the crucial alternate steps in purine metabolism [PMID: 17362992], and yeast N-carbamyl-beta-alanine amidohydrolase (betaAS, beta-alanine synthase) [PMID: 17916556, PMID: 14534321].

These enzymes are members of the broader family of amidases.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.