2-phospho-L-lactate transferase (IPR010115)

Short name: P-lactate_Trfase

Overlapping homologous superfamilies


Family relationships


This entry represents 2-phospho-L-lactate transferase or LPPG:Fo 2-phospho-L-lactate transferase (CofD). CofD catalyses the fourth step in the biosynthesis of coenzyme F420, which is the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP. F420 is a hydride carrier, important for energy metabolism of methanogenic archaea, as well as for the biosynthesis of other natural products, like tetracycline in Streptomyces. F420 and some of its precursors are also utilized as cofactors for enzymes, like DNA photolyase in Mycobacterium tuberculosis [PMID: 18252724, PMID: 11888293]. F420 is found in methanogens, Mycobacteria, and several other lineages. This enzyme is characterised so far in Methanocaldococcus jannaschii (Methanococcus jannaschii) [PMID: 11888293] but appears restricted to F420-containing species and is predicted to carry out the same function in these other species.

GO terms

Biological Process

GO:0051188 cofactor biosynthetic process

Molecular Function

GO:0000287 magnesium ion binding
GO:0016780 phosphotransferase activity, for other substituted phosphate groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.