LPPG:Fo 2-phospho-L-lactate transferase (IPR010115)

Short name: LPPG-Fo_P-lactate_Trfase

Family relationships


This entry contains LPPG:Fo 2-phospho-L-lactate transferase (CofD). CofD catalyses the fourth step in the biosynthesis of coenzyme F420, which is the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP. F420 is a flavin derivative found in methanogens, Mycobacteria, and several other lineages. This enzyme is characterised so far in Methanocaldococcus jannaschii (Methanococcus jannaschii) [PMID: 11888293] but appears restricted to F420-containing species and is predicted to carry out the same function in these other species.

GO terms

Biological Process

GO:0051188 cofactor biosynthetic process

Molecular Function

GO:0000287 magnesium ion binding
GO:0016780 phosphotransferase activity, for other substituted phosphate groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.