Flavoprotein WrbA-like (IPR010089)

Short name: Flavoprotein_WrbA-like

Overlapping homologous superfamilies

Family relationships


WrbA (tryptophan (W) repressor-binding protein) was discovered in Escherichia coli, where it was proposed to play a role in regulation of the tryptophan operon [PMID: 8516330], which has been put in question since then [PMID: 9694845]. Instead, WrbA has been shown to have FMN-dependent NAD(P)H:quinone oxidoreductase acivity [PMID: 16672604, PMID: 22952804]. A role in quinone detoxification has been proposed, supported by evidence suggesting its involvement in oxidative defense and/or cell signaling [PMID: 7756978, PMID: 12039722].

This entry also includes QR2 from Triphysaria versicolor. QR2 acts as a NAD(P)H:quinone oxidoreductase reducing quinones by a two-electron transfer mechanism [PMID: 11260494].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0010181 FMN binding
GO:0003955 NAD(P)H dehydrogenase (quinone) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.