Amino acid ABC transporter, permease protein, 3-TM domain (IPR010065)

Short name: AA_ABC_transptr_permease_3TM

Overlapping homologous superfamilies

Domain relationships


ABC transporters are minimally constituted of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These regions can be found on the same protein (mostly in eukaryotes and bacterial exporters) or on two different ones (mostly bacterial importers) [PMID: 9873074].

This entry represents the membrane component of a group of amino acid transport systems, such as histidine transport system HisM and HisQ subunits [PMID: 9520394, PMID: 24021237]. The region covered by this domain is predicted to contain three transmembrane helices in general. Substrate specificities attributed to permeases recognised by this entry include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline [PMID: 1987170].

GO terms

Biological Process

GO:0071705 nitrogen compound transport

Molecular Function

GO:0022857 transmembrane transporter activity

Cellular Component

GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.