Ni-containing CO dehydrogenase (IPR010047)

Short name: CODH

Overlapping homologous superfamilies

Family relationships


This entry describes the Ni-containing carbon monoxide dehydrogenase (CODH) family (EC: These enzymes reversibly oxidise CO to CO(2), and play key roles in the energy-yielding pathways of various autotrophic anaerobes, allowing these organisms to grow with CO as the sole carbon source [PMID: 15248760]. The active sites of these enzymes contain Ni-iron-sulphur (NiFeS) clusters. This family also includes the CODH subunit of bifunctional CODH/acetyl-CoA synthetase (CODH/ACS), which contains two Ni-containing active sites to catalyse the formation of acetyl-CoA from CO(2)-derived CO [PMID: 12627225, PMID: 15221479].

CODH is related to hybrid cluster proteins (HCP, or prismane) (IPR010048), a complex whose activity is not yet fully described; the hybrid Fe-S cluster in HCPs is similar to the NiFeS cluster in CODH [PMID: 14646063].

GO terms

Biological Process

GO:0006091 generation of precursor metabolites and energy
GO:0055114 oxidation-reduction process

Molecular Function

GO:0051539 4 iron, 4 sulfur cluster binding
GO:0018492 carbon-monoxide dehydrogenase (acceptor) activity
GO:0016151 nickel cation binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.