Methylthioadenosine phosphorylase (MTAP) (IPR010044)

Short name: MTAP

Family relationships


This entry represents the methylthioadenosine phosphorylase (MTAP). MTAP catalyses the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. It is involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. It is responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. It has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates [PMID: 2108157, PMID: 3091600].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0017061 S-methyl-5-thioadenosine phosphorylase activity
GO:0004645 phosphorylase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.