Diphthamide synthesis DHP2, eukaryotes (IPR010014)

Short name: DHP2_euk

Overlapping homologous superfamilies


Family relationships


DPH2 has been shown in Saccharomyces cerevisiae (Baker's yeast) to be one of several required for the modification of a particular histidine residue of translation elongation factor 2 to diphthamide [PMID: 8406038]. This modified site can then become the target for ADP-ribosylation by diphtheria toxin [PMID: 15485916]. DPH proteins are highly conserved among eukaryotes [PMID: 15485916].

GO terms

Biological Process

GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.