Family

Polyketide cyclase SnoaL-like (IPR009959)

Short name: Cyclase_SnoaL-like

Overlapping homologous superfamilies

Family relationships

None.

Description

Polyketides form a diverse group of compounds produced mainly by microorganisms and plants. This family of polyketide synthases includes aklanonic acid methyl ester cyclases, involved in the synthesis of aklavinone, an intermediate in the biosynthetic pathway of clinically important anthracyclines such as daunorubicin and doxorubicin [PMID: 10200167, PMID: 7836284]. SnoaL belongs to this family; it is involved in nogalamycin biosynthesis [PMID: 15071504].

SnoaL adopts a distorted alpha-beta barrel fold [PMID: 15071504]. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation [PMID: 15071504].

GO terms

Biological Process

GO:0030638 polyketide metabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam