Domain

Polyketide cyclase SnoaL-like domain (IPR009959)

Short name: Cyclase_SnoaL-like_dom

Domain relationships

None.

Description

This domain is found in SnoaL [PMID: 15071504] a polyketide cyclase involved in nogalamycin biosynthesis. This domain was formerly known as DUF1486. It adopts a distorted alpha-beta barrel fold [PMID: 15071504]. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation [PMID: 15071504].

This entry represents a SnoaL-like domain that is found in SnoaL and a in large number of other sequences.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
Pfam