NADH:ubiquinone oxidoreductase subunit B14.5a (IPR009947)

Short name: NADH-UbQ_OxRdtase_B14.5a_su

Overlapping homologous superfamilies


Family relationships



NADH:ubiquinone oxidoreductase (complex I) (EC: is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [PMID: 1470679]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [PMID: 10940377], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins [PMID: 18394423].

This family contains the eukaryotic NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a). This is approximately 100 residues long, and forms part of a multiprotein complex that resides on the inner mitochondrial membrane [PMID: 9878551].

GO terms

Biological Process

GO:0042773 ATP synthesis coupled electron transport

Molecular Function

GO:0008137 NADH dehydrogenase (ubiquinone) activity

Cellular Component

GO:0005743 mitochondrial inner membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.