Family

Inner membrane protein YgfX (IPR009883)

Short name: YgfX

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

This family includes bacterial proteins including the probable inner membrane protein YgfX from Escherichia coli (formerly known as CptA). This had been thought to be a toxin, but it has no effect on cell growth [PMID: 23657679]. It has been shown to interacts with the cytoskeletal proteins FtsZ and MreB and to inhibit FtsZ GTP-dependent and MreB ATP-dependent polymerization [PMID: 22239607]. In Serratia strains deficient in sdhE-ygfX, YgfX restores production of the antibiotic prodigiosin [PMID: 22474332].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom
PIRSF
Pfam