Hematopoietic cell signal transducer (IPR009861)

Short name: HCST

Overlapping homologous superfamilies


Family relationships



Hematopoietic cell signal transducer (HCST, also known as DAP10) is a transmembrane adaptor that associates with an activation receptor, NKG2D, which is found on NK and subsets of T cells. The ligands for this receptor include MHC class I chain-related (MIC) protein A and protein B and UL16-binding proteins [PMID: 18097042]. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells [PMID: 12740576].

GO terms

Biological Process

GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0050776 regulation of immune response

Molecular Function

GO:0043548 phosphatidylinositol 3-kinase binding
GO:0005102 signaling receptor binding

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.