Protein of unknown function DUF1396, LppX/LprAFG lipoprotein (IPR009830)

Short name: DUF1396

Family relationships



This entry consists of several lipoproteins from Mycobacterium species, collectively known as the LppX/LprAFG family. The best characterised of these is LprG (P0A5I8) from Mycobacterium tuberculosis which is an immunogenic 27 kDa membrane-associated lipoprotein [PMID: 9387238]. Expression of the lprG gene encoding this protein is essential for the growth of M. tuberculosis in immunocompetent mice [PMID: 14998516]. Purification of LprG showed that it inhibits MHC-II antigen processing in primary human macrophages, providing a mechanism to avoid the host MHC-II-restricted CD4+ T cell response which is considered essential for control of M. tuberculosis infection [PMID: 15294983]. LppX is a secreted antigen which may be a good target for vaccine design [PMID: 14723617], while LprF is a membrane lipoprotein involved in the kdp signal transduction pathway, thought to be the primary response to osmotic stress [PMID: 12581360].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.