Selenoprotein S (IPR009703)

Short name: Selenoprotein_S

Overlapping homologous superfamilies


Family relationships



This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types. These proteins are involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins which participate in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner [PMID: 12477932]. They probably serve as a linker between DER1, which mediates the retro-translocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.

GO terms

Biological Process

GO:0006886 intracellular protein transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030176 integral component of endoplasmic reticulum membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.