Programmed cell death protein 10 (IPR009652)

Short name: PDCD10

Overlapping homologous superfamilies


Family relationships



Programmed cell death 10 protein (PDCD10/CCM3) is part of the CCM complex and is required for neuronal migration [PMID: 24595293]. It also has roles outside of this complex [PMID: 20229348]. PDCD10/CCM3 was originally discovered to be upregulated during granulocyte apoptosis and is thought to play a role in cell death [PMID: 20229348]. However, a specific role for PDCD10 in cell survival is not clear as both pro-survival and pro-apoptopic effects have been reported [PMID: 24481819]. PDCD10/CCM3 contains an N-terminal dimerisation domain and a C-terminal focal adhesion targeting-homology (FAT-H) domain [PMID: 24481819].

There are three CCM proteins: CCM1 (also known as KRIT1), CCM2 (also known as OSM and malcavernin) and CCM3 (also known as PDCD10). Mutations in the genes encoding CCM proteins cause cerebral cavernous malformations (CCMs), a disease characterised by dilated leaky blood vessels, especially in the neurovasculature, that result in increased risk of stroke, focal neurological defects and seizures. The CCM proteins can form a trimeric complex. They can also interact with a range of signaling, cytoskeletal and adaptor proteins that may account for their roles in a range of basic cellular processes including cell adhesion, migration, polarity and apoptosis [PMID: 24481819].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.