Domain

LsmAD domain (IPR009604)

Short name: LsmAD_domain

Domain relationships

None.

Description

This entry represents a conserved region approximately 250 residues long located on eukaryotic ataxin-2 [PMID: 16115810]. Ataxin-2 is a protein of unknown function, within which expansion of a polyglutamine tract (due to expansion of unstable CAG repeats in the coding region of the SCA2 gene) causes spinocerebellar ataxia type 2 (SCA2), a late-onset neurodegenerative disorder [PMID: 9339681]. The expanded polyglutamine repeat in ataxin-2 causes disruption of the normal morphology of the Golgi complex and increased incidence of cell death [PMID: 12812977]. Ataxin-2 is predicted to consist of mostly non-globular domains [PMID: 9462862].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam