GPI transamidase subunit PIG-U (IPR009600)

Short name: PIG-U

Overlapping homologous superfamilies


Family relationships



Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the C terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subunit in this complex and may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI [PMID: 12802054].

GO terms

Biological Process

GO:0016255 attachment of GPI anchor to protein

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0042765 GPI-anchor transamidase complex
GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.