Domain

Vacuolar protein sorting-associated protein 13, SHR-binding domain (IPR009543)

Short name: SHR-BD

Domain relationships

None.

Description

This entry represents a domain, known as SHR-BD, found in vacuolar protein sorting-associated protein 13 (VPS13). In plants, this domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY (Q9FT44) [PMID: 2344435].

Proteins containing this domain may play a role in the control of protein cycling through the trans-Golgi network. Vacuolar sorting protein is an ATPase required for endosomal trafficking [PMID: 10637304]. Defects in the human protein VPS13A cause chorea-acanthocytosis, an autosomal recessive neurodegenerative disorder characterised by the gradual onset of hyperkinetic movements and abnormal erythrocyte morphology [PMID: 11381253].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam