Family

Vang-like protein (IPR009539)

Short name: VANGL

Family relationships

None.

Description

VANGL proteins play important roles in the establishment of planar cell polarity (PCP) [PMID: 24981109]. Vangl2 is required for retinal axon guidance [PMID: 25990804], kidney-branching morphogenesis and glomerular maturation [PMID: 20843830]. It also plays a role in the orientation of stereociliary bundles in the cochlea and is required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process [PMID: 15637299]. It is required for cell surface localization of FZD3 and FZD6 in the inner ear [PMID: 16495441].

GO terms

Biological Process

GO:0007275 multicellular organism development

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER
PIRSF