Borna disease virus P24 (IPR009517)

Short name: BDV_P24

Overlapping homologous superfamilies


Family relationships



Borna disease virus (BDV) is a non-cytolytic, neurotropic RNA virus that has a broad host range in warm-blooded animals. BDV is an enveloped virus, non-segmented, negative-stranded RNA genome and has an organisation characteristic of a member of Bornaviridae in the order of Mononegavirale. This family consists of several BDV P24 (phosphoprotein 24) proteins. They are essential components of the RNA polymerase transcription and replication complex.

P24 is encoded by open reading frame II (ORF-II) and undergoes high rates of mutation in humans. They bind amphoterin-HMGB1, a multifunctional protein, directly may cause deleterious effects in cellular functions by its interference with HMGB1 [PMID: 14581561]. Horse and human P24 have no species-specific amino acid residues, suggesting that the two viruses related [PMID: 8523585, PMID: 9811743].

Numerous interactions of the immune system with the central nervous system have been described. Mood and psychotic disorders, such as severe depression and schizophrenia, are both heterogeneous disorders regarding clinical symptomatology, the acuity of symptoms, the clinical course and the treatment response [PMID: 18623121]. BDV p24 RNA has been detected in the peripheral blood mononuclear cells (PBMCs) of psychiatric patients with such conditions [PMID: 9811743]. Some studies find a significant difference in the prevalence of BDV p24 RNA in patients with mood disorders and schizophrenia [PMID: 16324750], whilst others find no difference between patients and control groups [PMID: 9811743]. Consequently, debate about the role of BDV in psychiatric diseases remains alive.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.