Transcription activator, Churchill (IPR009508)

Short name: Transcrpt_activator_Churchill

Family relationships



This family consists of several eukaryotic Churchill proteins. This protein contains a novel zinc binding region that mediates FGF signalling during neural development. The slow induction by FGF of a transcription factor (Churchill) in the neural plate in turn induces expression of Sip1 (Smad interacting protein-1), which inhibits mesodermal genes and sensitizes cells to later neural inducing factors [PMID: 14651843].

GO terms

Biological Process

GO:0007275 multicellular organism development
GO:0045893 positive regulation of transcription, DNA-templated

Molecular Function

GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.