This conserved region is found in the N-terminal half of several Spondin proteins [PMID: 19153605]. Spondins are involved in patterning axonal growth trajectory through either inhibiting or promoting adhesion of embryonic nerve cells [PMID: 11287656].
Li Y, Cao C, Jia W, Yu L, Mo M, Wang Q, Huang Y, Lim JM, Ishihara M, Wells L, Azadi P, Robinson H, He YW, Zhang L, Mariuzza RA.
Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. EMBO J. 28 286-97 2009
Tzarfati-Majar V, Burstyn-Cohen T, Klar A.
F-spondin is a contact-repellent molecule for embryonic motor neurons. Proc. Natl. Acad. Sci. U.S.A. 98 4722-7 2001
Signatures from InterPro member databases are used to construct an entry.